雙足平衡測試儀是通過大鼠、小鼠自身的平衡調(diào)節(jié)來評估疼痛程度的方法。

動物的雙腳分別著力于兩塊不同的稱重板上正常鼠會將體重平均分配到兩只腳上兩個測重板的數(shù)據(jù)差值很小；如果其中一只腳存在發(fā)炎、病變或神經(jīng)疼痛根據(jù)嚴(yán)重程度老鼠會自發(fā)地將體重轉(zhuǎn)移到另外一只腳上導(dǎo)致兩塊測重板的重量出現(xiàn)相應(yīng)的差值。該方法在藥篩和安評中被廣泛應(yīng)用。

雙足平衡測量來評價(jià)疼痛與壓力測痛儀測量的結(jié)果具有很好的相關(guān)性。

功能

· 全自動測試操作方便
· 觸屏操作USB導(dǎo)出數(shù)據(jù)Excel格式輸出
· 磁性腳墊設(shè)計(jì)易于組裝和清洗
· 適用于大鼠和小鼠

型號47883/47882

產(chǎn)品特點(diǎn)

被廣泛使用的方法

· 引用次數(shù)超過1500次；

· 測量后肢的重量分布該方法在新款的Ugo Basile設(shè)備中得到更新；

自動測試功能 

· 具備自動化開啟測量模式使整個實(shí)驗(yàn)過程更簡單和省力；

觸屏操作和USB數(shù)據(jù)存儲功能

· 可以快速設(shè)定參數(shù)控制儀器和管理數(shù)據(jù)；

· 數(shù)據(jù)可直觀顯示；

· 附帶移動U盤可以存儲所有測試數(shù)據(jù)（包括平均爪重標(biāo)準(zhǔn)偏差左右比率等）

· 數(shù)據(jù)能夠以圖表形式直觀實(shí)時；

結(jié)果精確可靠

· 高精度力傳感器分辨率為0.1g；

· 校正簡單；

· 非常耐用沒有其它易損或需要經(jīng)常更換部件；

· 數(shù)據(jù)重現(xiàn)性好；

· 每次實(shí)驗(yàn)后結(jié)果可以自行篩選數(shù)據(jù)可通過軟件導(dǎo)出兼容EXCEL格式的文件；

便于清洗

· 磁性腳墊設(shè)計(jì)易容移除和固定；

· 平板式設(shè)計(jì)沒有死角容易清理；

大鼠和小鼠測試鼠籠

實(shí)時的測量數(shù)據(jù) 

用于將csv數(shù)據(jù)導(dǎo)出到PC的USB密鑰和各連接器

產(chǎn)品主要規(guī)格

小鼠雙足平衡測試儀

大鼠雙足平衡測定儀

雙足平衡測定儀的部分相關(guān)文獻(xiàn)

1.Argueta, Donovan A., et al. "Palmitoylethanolamide Attenuates Pain-like Behavior in Factor VIII Deficient Mice." Blood 140.Supplement 1 (2022)5578-5579.doi10.1182/blood-2022-159745
IF 25.48
2.Shi, Yuanyuan et al. “A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development." Nature communications vol. 10,1 1914. 23 Apr. 2019, doi:10.1038/s41467-019-09839-x
IF17.69
3.Cao, Chenxi et al. “Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4." Nature communications vol. 13,1 7139. 21 Nov. 2022, doi:10.1038/s41467-022-34830-4
IF17.69
4.Kwon, Hyuk-Kwon et al. “A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice." Experimental & molecular medicine vol. 51,4 1-19. 26 Apr. 2019, doi:10.1038/s12276-019-0244-0
IF12.15
5.Batchelor, V., J. Miotla-Zarebska, and T. L. Vincent. "REFINING METHODS TO MEASURE SPONTANEOUS PAIN BEHAVIOUR IN SURGICALLY INDUCED MURINE OSTEOARTHRITIS." Osteoarthritis and Cartilage 30 (2022)S381. doi10.1016/j.joca.2022.02.513
IF 7.51
6.Cheng, Jin, et al. "RIP1 perturbation induces chondrocyte necroptosis and promotes osteoarthritis pathogenesis via targeting BMP7." Frontiers in Cell and Developmental Biology 9 (2021)638382. doi:10.3389/fcell.2021.638382
IF 6.08
7.Sur, Bongjun et al. “Inhibition of Carrageenan/Kaolin-Induced Arthritis in Rats and of Inflammatory Cytokine Expressions in Human IL-1β-Stimulated Fibroblast-like Synoviocytes by a Benzylideneacetophenone Derivative." Inflammation vol. 42,3 (2019)928-936. doi:10.1007/s10753-018-0947-8
IF4.66
8.Villa, Thea et al. “Fangchinoline Has an Anti-Arthritic Effect in Two Animal Models and in IL-1β-Stimulated Human FLS Cells." Biomolecules & therapeutics vol. 28,5 (2020)414-422. doi:10.4062/molther.2020.113
IF4.23
9.Carlesso, Lisa C et al. “Use of IMMPACT Recommendations to Explore Pain Phenotypes in People with Knee Osteoarthritis." Pain medicine (Malden, Mass.) vol. 23,10 (2022)1708-1716. doi:10.1093/pm/pnac044
IF3.64
10.Surcheva, Slavina, et al. "Preclinic and clinic effectiveness of gabapentin and pregabalin for treatment of neuropathic pain in rats and diabetic patients." Biotechnology & Biotechnological Equipment 31.3 (2017)568-573.doi10.1080/.2017.1290550
IF:1.77
11.Miotla-Zarebska, Jadwiga et al. “Modeling and Assessing Osteoarthritis in Mice by Destabilization of the Medial Meniscus (DMM)." Methods in molecular logy (Clifton, N.J.) vol. 2598 (2023)357-373. doi:10.1007/978-1-0716-2839-3_26
IF0.39

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