詳細(xì)介紹
動(dòng)態(tài)足底觸覺儀是評(píng)估大鼠、小鼠足底對(duì)觸覺敏感性的測(cè)試設(shè)備。
動(dòng)物模型的刺痛測(cè)試與分析在藥物診斷、理學(xué)和機(jī)體損傷性研究等多種研究領(lǐng)域有著廣泛的應(yīng)用。

型號(hào)37550
主要特色
· 自動(dòng)檢測(cè)動(dòng)物反應(yīng)無需人為判斷;
· 可調(diào)節(jié)施加力的測(cè)試速率;
· 帶統(tǒng)計(jì)和分析軟件;
· 可通過U盤進(jìn)行數(shù)據(jù)拷貝;
· 可選配打印機(jī)對(duì)數(shù)據(jù)進(jìn)行打??;
· 可選配鼠筒可進(jìn)行口部、面部刺激;
測(cè)試主機(jī)
觸覺刺激器
測(cè)試主機(jī)顯示面板
主要配置
· 便攜和易用移動(dòng)的觸覺刺激器配有剛性探針和可調(diào)節(jié)角度的鏡子;
· 控制主機(jī)帶觸控屏顯示直觀操作方便;
· 十字孔板測(cè)試平臺(tái);
· 模塊化動(dòng)物鼠籠使用隔板可分配成3個(gè)大鼠鼠籠和12個(gè)小鼠鼠籠測(cè)試單元;
電控型測(cè)試探針
測(cè)試平臺(tái)
十字測(cè)試網(wǎng)格
設(shè)備的操作
· 大鼠、小鼠被放置到測(cè)試平臺(tái)上用測(cè)試鼠籠約束;
· 受試動(dòng)物在鼠籠內(nèi)科自由活動(dòng);
· 給出一定的環(huán)境適應(yīng)時(shí)間和老鼠的探索時(shí)間;
· 操作人員將觸覺刺激器放置在動(dòng)物爪子正下方在反光鏡的幫助下定位硬絲;
· 啟動(dòng)觸覺刺激器的按鈕開始測(cè)試;
A剛性探針被自動(dòng)抬高;
B探針接觸足底后開始施力;
C力度以預(yù)設(shè)施力速率增加直到動(dòng)物移除爪子或達(dá)到預(yù)設(shè)力度自動(dòng)停止加力;
· 自動(dòng)記錄兩個(gè)測(cè)試指標(biāo)縮爪的潛伏期(單位S)和縮爪時(shí)的力度(單位g)
主要規(guī)格
啟動(dòng) 觸覺刺激器上的按鍵 式操作
力度范圍 0.5-50g
力度分辨率 0.1g(0.5-5g)0.5g(5-50g)
力增加速率可調(diào)范圍 1-20s
剛性探針直徑 0.5mm
硬絲探針的行程 12mm
潛伏期精度 0.1s
數(shù)據(jù)連接 可通過 DELTA 9 針連接器連接到電腦
數(shù)據(jù)的采集
· 測(cè)試主機(jī)可直觀顯示測(cè)試數(shù)據(jù)并對(duì)數(shù)據(jù)進(jìn)行存儲(chǔ);
· 數(shù)據(jù)可導(dǎo)出到電腦或者使用專用U盾進(jìn)行數(shù)據(jù)拷貝;
· 通信由基于CUB Data Acquisition Windows®的專用軟件包52050-10管理;
· 能夠?qū)?shí)驗(yàn)數(shù)據(jù)傳送到電腦并使用常用軟件進(jìn)行管理;
· 配備了存儲(chǔ)鍵用于記錄回顧實(shí)驗(yàn)數(shù)據(jù);
· 支持使用遠(yuǎn)程網(wǎng)絡(luò)連接測(cè)試主機(jī)對(duì)實(shí)驗(yàn)參數(shù)進(jìn)編輯;
參考文獻(xiàn)
1.Fri??i?, Jasna, et al. "The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts." Immunity 54.5 (2021):
1002-1021. doi10.1016/j.immuni.2021.03.003
2.Boyd, Jacob T., et al. "Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions."
Nature metabolism 3.6 (2021)762-773.doi:
3.Defaye, Manon, et al. "The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain." The Journal of clinical investigation 132.12 (2022).doi:
10.1172/JCI154317
4.Liu, Shijia, et al. "Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions." Neuron 110.5 (2022)857-873. doi10.1016/j.neuron.2021.11.029
5.Powell, Rasheen, et al. "Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior." Nature Communications 12.1 (2021)5812.
10.1038/s41467-021-26100-6
6.Cheong, Hogyun, et al. "Sutureless neurorrhaphy system using a macrophage-polarizing in situ visible light-crosslinkable adhesive protein hydrogel for functional
nerve regeneration." Chemical Engineering Journal 445 (2022)136641. doi:10.1016/j.cej.2022.136641
7.Llorca-Torralba, Meritxell, et al. "Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons." Brain 145.1 (2022)154-167. doi:
10.1093/brain/awab239
8.Sohn, Hee Su, et al. "Tolerogenic nanoparticles induce type II collagen?specific regulatory T cells and ameliorate osteoarthritis." Science Advances 8.47 (2022):
eabo5284.doi10.1126/sciadv.abo5284
9.Fotio, Yannick, et al. "NAAA-regulated lipid signaling governs the transition from acute to chronic pain." Science advances 7.43 (2021)eabi8834.doi10.1126/sciadv.abi8834
10.Kolbinger, Anja, et al. "Eosinophil‐derived IL‐4 is necessary to establish the inflammatory structure in innate inflammation." EMBO Molecular Medicine 15.2
(2023)e16796.doi:
3007536621
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