摘要 　 目的:評(píng)價(jià)鹽酸***的精神依賴性潛力。方法:大鼠靜脈自身給藥法。結(jié)果:與生理鹽水自身對(duì)照相比 ,
鹽酸***在點(diǎn)燃劑量015 mg· kg- 1
和梯度劑量0125 mg· kg- 1
下 ,觸鼻次數(shù)顯著增加 , P < 01001 , 均形成穩(wěn)定的自
身給藥行為;而兩種不同劑量下鹽酸***的日攝入總量(total daily dose , TDD)無(wú)顯著性差異。結(jié)論:鹽酸***
具有較強(qiáng)的精神依賴性潛力。
關(guān)鍵詞 　 靜脈自身給藥; 鹽酸***; 精神依賴性
ASSESSMENT OF OXYCODONE HYDROCHLORIDE INDUCED PSYCHIC DEPENDENCE
BY INTRAVENOUS SELF - ADMINISTRATION IN RATS
HA Ying , WANGWeiping
( National Institute on Drug Dependence , Peking University , Beijing , 100083)
ABSTRACT 　Objective : To assess the psychic dependence potential of oxycodone hydrochloride.
Methods : The technique of intravenous self - administration by rats was utilized. Under fixed - ratio = 1
schedule of drug injection , one nose - poke response result in drug delivery to the rat . Results : All the rats
trained with oxycodone at dose 015 mg· kg - 1
showed self - administration behavior. The number of nose - poke
response to oxycodone was much more than that to saline ( P < 01001) . As the dose of oxycodone hydrochlo2
ride lowered to 0125 mg· kg- 1
, the number of nose - poke response to oxycodone increased significantly ( P <
01001) , while the total daily dose (TDD) of oxycodone hydrochloride infusions changed insignificantly ( P >
0105) . Conclusion : Oxycodone hydrochloride has psychological dependence potential .
KEY WORDS　self - administration ; oxycodone hydrochloride ; psychological dependence